White Paper — The Beauty of Microbial Natural Products: Selective Polypharmacology ≠ Promiscuity
By Ross Youngs, October 10, 2025 White Paper — The Beauty of Microbial Natural Products Abstract: For decades, the ‘one‐drug, one‐target’ paradigm shaped discovery strategies. Although this approach yielded many important medicines, it often underperforms against complex, multi‐factorial diseases in which networks of proteins and pathways adapt to single node blockade. Network pharmacology reframes this challenge by embracing polypharmacology—intentional, selective engagement
Continue ReadingThe Evolutionary Advantage: Why Microbial Chemistry Wins in Drug Discovery & Approval
By Ross Youngs, September 23, 2025 The Evolutionary Advantage: Why Microbial Chemistry Wins in Drug Discovery & Approval Quantifying Success and Capitalized Cost Savings from Lead Identification Executive Summary The classic ‘magic‐bullet’ strategy—maximally selective ligands for single targets—is well suited to simple causal architectures but less effective for diseases driven by robust and redundant networks (e.g., cancer, metabolic and neurodegenerative disorders).
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Ross Youngs “A conversation with a genius”
By Ross Youngs, November 27, 2024 “A conversation with a genius” Key points: The bottleneck in drug discovery suggests we need 1,000,000,000,000,000,000,000,000,000 years or more. Even with generous assumptions and the full force of global computing power, creating and testing all possible drug-like molecules within a reasonable timeframe remains a distant prospect. However, this thought experiment
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Engineers Versus Scientists ChatGPT
By Ross Youngs, March 24, 2023. Engineers Versus Scientists ChatGPT Just some leading questions to ChatGPT with responses and pushback. A fun Friday read. I am focused on executing a new technology to bring the best small molecules into drug discovery research, and funding sources always ask what is your clinical proof – or what is
Continue ReadingNatural Small Molecule Complexity – Evolution Keeps What Works
By Ross Youngs, March 5, 2023. Natural Small Molecule Complexity – Evolution Keeps What Works For decades the promise of obtaining the genetic codes of organisms created a narrative that cures and treatments would quickly follow. The human genome project had a lofty promise and failed to meet even the slightest realization of cures and treatments.
Continue Reading12 QUESTIONS to ChatGPT MICROBIOME DISCOVERY
By Ross Youngs, February 2, 2023. 12 QUESTIONS to ChatGPT MICROBIOME DISCOVERY Chat GPT from OpenAI is a new and interesting way of interrogating the universe of data online and formulating it into a cohesive human communication format. To prove the point that this will be part of the next generations of human efficiency improvement that
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TOP 50 Microbiome posts out of hundreds of posts as rated by Impressions 1,300,000 + Impressions on LinkedIn
By Ross Youngs, January 18, 2023. TOP 50 Microbiome posts out of hundreds of posts as rated by Impressions 1,300,000 + Impressions on LinkedIn The impression created a ranking of Ross’ Microbiome Posts on LinkedIn’s TOP 50 ~ 2022 review. Learn More
Continue ReadingYour DNA Doesn’t Control Your Health.
By Marcia Santos Sadler, August 5, 2022. Biosortia is busy mining, not Bitcoin but, Microbes. Biosortia is doing what works in a way nobody ever thought possible or scalable. By providing target-hitting small molecules and datasets using deep access to previously unculturable microbes and their molecules. A valuable and proven source for the future of therapeutics.
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Discover the Real Chemistry of Life with Microbiome Mining
By Ross Youngs, March 12, 2019. What’s on the horizon? People have always been curious about the world’s next significant technological opportunity. Indeed, curiosity about the unknown has been the cornerstone of society’s greatest advancements. Albert Einstein knew this when he said, “The most beautiful thing we can experience is the mysterious. It is the source
Continue ReadingDisruption in the Technology Age
By Ross Youngs, March 12, 2019. Disruption in the Technology Age Seems to Happen in Unexpected Places How new drug discovery will be impacted by a surrogate microbiome New York City, New York (March 12, 2019) – The pharmaceutical, agrochemical, and cosmetic industries all have similar pathways to discovering new products. Historically, all three sectors have
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