By Ross Youngs, November 26, 2025. Microbiome Metabolic Fingerprinting: The Critical Control Layer for Deep Space Survival and Terrestrial Health (D2) The two defining challenges of the coming century—reversing the decline in pharmaceutical R&D productivity on Earth and enabling sustainable human habitation in space—are usually treated as separate problems. In reality,…

By Ross Youngs, November 25, 2025. Unveiling Hidden Microbial . . . GLP-1 [video_popup url="https://www.youtube.com/watch?v=xOv5lPKq1KQ" text="WATCH NOW"]  Breaking Research: A Differentiated, Oral Approach to Weight Management is Emerging from the Microbial "Dark Matter. "Our latest white paper, "Unveiling Hidden Microbial Metabolites for Polypharmacology in Obesity Therapeutics" (Draft 2), reveals a novel,…

By Ross Youngs, October 31, 2025. Reversing Eroom’s Law: Finitude and Dilution in Small-Molecule Discovery Abstract Drug discovery productivity—measured as clinically viable new molecules per research has declined for decades, a trend known as Eroom’s Law. This paradox persists despite advances in screening, computing, and artificial intelligence. Here we show that…

By Ross Youngs,  July 26, 2025 A New Paradigm for Accredited Investors: Equity vs. Direct Asset Tokenization Impact for funding under Reg D by the Newly Approved National Legislation Abstract Drug discovery productivity—measured as clinically viable new molecules per research has declined for decades, a trend known as Eroom’s Law.…

By Ross Youngs, October 10, 2025 White Paper — The Beauty of Microbial Natural Products Abstract: For decades, the 'one‐drug, one‐target' paradigm shaped discovery strategies. Although this approach yielded many important medicines, it often underperforms against complex, multi‐factorial diseases in which networks of proteins and pathways adapt to single node blockade.…

By Ross Youngs, September 23, 2025 The Evolutionary Advantage: Why Microbial Chemistry Wins in Drug Discovery & Approval Quantifying Success and Capitalized Cost Savings from Lead Identification Executive Summary The classic 'magic‐bullet' strategy—maximally selective ligands for single targets—is well suited to simple causal architectures but less effective for diseases driven by…

By Ross Youngs, November 27, 2024 "A conversation with a genius" Key points: The bottleneck in drug discovery suggests we need 1,000,000,000,000,000,000,000,000,000 years or more. Even with generous assumptions and the full force of global computing power, creating and testing all possible drug-like molecules within a reasonable timeframe remains a distant…

By Ross Youngs, March 24, 2023. Engineers Versus Scientists ChatGPT Just some leading questions to ChatGPT with responses and pushback. A fun Friday read. I am focused on executing a new technology to bring the best small molecules into drug discovery research, and funding sources always ask what is your clinical…

By Ross Youngs, March 5, 2023. Natural Small Molecule Complexity - Evolution Keeps What Works For decades the promise of obtaining the genetic codes of organisms created a narrative that cures and treatments would quickly follow. The human genome project had a lofty promise and failed to meet even the slightest…

By Ross Youngs, February 2, 2023. 12 QUESTIONS to ChatGPT MICROBIOME DISCOVERY Chat GPT from OpenAI is a new and interesting way of interrogating the universe of data online and formulating it into a cohesive human communication format. To prove the point that this will be part of the next generations…